Welcome to the Transplantation Research Lab

What we do...

The Transplantation Research Lab is dedicated to the discovery of new and more effective methods for preventing and managing the rejection of transplanted organs. 

Current projects include:

  • Understanding how regulatory T cells (specialized immune cells) prevent autoimmune diabetes and transplant rejection
  • Engineering dendritic cells (DCs) to inhibit donor-specific T cells and targeting DCs to lymphoid organs
  • Investigational use of the immunosuppressive drug called Belatacept to control graft rejection
  • Studying the effects of gaseous carbon monoxide to increase anti-inflammatory response
  • Establishing successful protocols for withdrawal from immunosuppressive regimens

Recent Publications

Brennan TV, Jaigirdar A, Hoang V, Hayden T, Liu FC, Zaid H, Chang CK, Bucy RP, Tang Q, Kang SM
Preferential priming of alloreactive T cells with indirect reactivity.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Apr-01-2009; 94: 709-18.
Melli K, Friedman RS, Martin AE, Finger EB, Miao G, Szot GL, Krummel MF, Tang Q
Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues.
Journal of immunology (Baltimore, Md. : 1950), Mar-01-2009; 1825: 2590-600.
Brennan TV, Hoang V, Garrod KR, Liu FC, Hayden T, Kim J, Kang SM
A new T-cell receptor transgenic model of the CD4+ direct pathway: level of priming determines acute versus chronic rejection.
Transplantation, Jan-27-2008; 852: 247-55.
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